Table 2.
Levels of Inflammatory Markers in the Older Adult Sample
| Inflammatory Marker | Median (IQR) | Mean (± SD) |
|---|---|---|
| Systemic inflammation (n = 173)a | ||
| CRP, mg/L | 1.0 (0.5–2.8) | |
| IL-6, pg/mL | 1.6 (1.3–2.9) | |
| sTNF-RII, ng/mL | 2.6 (2.2–3.1) | |
| Cellular inflammation (n = 168)b | ||
| Monocytes producing IL-6 only, % | 25.1 (16.0) | |
| Monocytes producing TNFα only, % | 37.3 (14.6) | |
| Monocytes coproducing IL-6 + TNFα, % | 16.7 (11.3) | |
| Nuclear signaling (n = 123)c | ||
| NF-κB, MFI | ||
| PBMC | 27.4 (14.5) | |
| Monocyte | 42.9 (35.6) | |
| Lymphocyte | 21.7 (8.5) | |
| STAT1, MFI | ||
| PBMC | 36.0 (8.9) | |
| Monocyte | 65.4 (12.1) | |
| Lymphocyte | 24.5 (7.7) | |
| STAT3, MFI | ||
| PBMC | 26.2 (11.1) | |
| Monocyte | 44.7 (15.8) | |
| Lymphocyte | 18.7 (9.4) | |
| STAT5, MFI | ||
| PBMC | 29.2 (6.4) | |
| Monocyte | 48.2 (10.9) | |
| Lymphocyte | 21.8 (5.8) |
Notes: CRP = C-reactive protein; IL-6 = interleukin-6; IQR = interquartile range; NF-κB = nuclear factor kappa B; MFI = mean fluorescence intensity; TNFα = tumor necrosis factor alpha; sTNF-RII = soluble tumor necrosis factor receptor II; STAT = signal transducer and activator of transcription; PBMC = peripheral blood mononuclear cells.
aSystemic (circulating) marker data were natural log-transformed for analyses, but nontransformed median and IQR are shown for ease of interpretation. bNet percentages of toll-like receptor-4 (TLR-4)-stimulated monocytes producing IL-6 only, producing TNFα only, and coproducing both IL-6 and TNFα simultaneously. cSpontaneous intranuclear levels of activated NF-κB, STAT1, STAT3, and STAT5 were assayed in total PBMC, as well as monocyte and lymphocyte subsets.