. 2019 Sep 5;18(5):3439–3449. doi: 10.3892/etm.2019.7975

Table I.

A total of 378 DEGs identified from three profile datasets, including 240 upregulated genes and 138 downregulated genes in the glioblastoma tissues compared with normal brain tissues.

DEGs	Gene names
Upregulated	RALYL GLT1D1 STOX1 GNAL HCN1 GOT1 UNC5A RAB40B BSN PRKCB CA11 KCNA1 SRRM4 CARNS1 ZNF385B CABP1 SLC6A15 RBFOX1 RAB3A CLCN4 CRHBP NEBL HLF IGSF8 SLC39A12 IDS MFSD4A FRMPD4 ATP2B2 RIMBP2 MAP7 C1orf115 OTUD7A RAB11FIP4 NEGR1 MAP1A REPS2 CD200 GAD2 HPCAL4 SST GRM1 ERC2 TRHDE RASGEF1A RIMS1 PHF24 GRIN2A SHANK3 IL1RAPL1 KIF5C GABRA1 UBE2QL1 CACNA2D2 SYN2 GRM3 NEUROD2 KIAA0513 KIAA1644 GNG3 SLC8A2 PPFIA2 PIP4K2A MYT1L LINGO2 IPCEF1 NRG3 OSBPL1A NRGN UNC13A KCNJ3 MOBP NEURL1 NTSR2 CPLX2 FBXL16 RAPGEF5 KCNV1 DGKE KIRREL3 GABRA5 NRXN3 STXBP1 HOOK1 PPP1R1A KCNQ3 ATRNL1 TPPP ATP8A2 ATP2B3 SLIT2 OLFM3 STMN2 ADAM11 SYT4 MAP3K9 YPEL2 SLC6A17 PPIP5K1 HECW1 VAMP2 ROGDI RBFOX3 SYNGR3 GJB6 CACNA1E CNTN4 CHST1 RAP1GAP2 VAMP1 FRRS1L CREG2 CEP170B CPLX1 SYN1 MPPED1 ADCY5 MAL CACNA1B SLC7A14 OLFM1 GABRG1 EPB41L1 KIAA1549L PCLO SV2B FABP3 KCNJ9 SNAP25 ANKS1B SPOCK3 JAKMIP1 SH3GL3 RIMS3 FGFR2 GABRB2 RGS7 NPM2 SVOP ITPR1 KIF5A PKP4 CNTNAP4 PAK3 PPP2R2C RUNDC3B WBSCR17 MAP7D2 CCK DOK6 CSMD1 CDKL2 SLC17A7 S100A1 BRINP1 CELF3 RXFP1 SLC35F3 SULT4A1 KHDRBS2 RAPGEF4 PDE1A OPALIN GPR26 DNAJC6 SRCIN1 ETNPPL SYT1 EDIL3 CNNM1 DLG2 CYP4X1 PACSIN1 TBC1D30 STXBP6 CACNG8 MTURN NELL1 PLCL1 C11orf87 TBR1 ASIC2 CAMK2A FAIM2 GRM5 CACNG3 DDN ST8SIA3 NECAB1 ATP8A1 IQSEC1 LRRC7 LINC00889 CDK5R1 RYR2 FEZF2 NIPAL3 CAMK1D DYNC1I1 ARHGAP44 SLC12A5 RUSC2 PAIP2B NKAIN2 PPP1R16B KIAA0319 CHD5 MYRIP ACSL6 PITPNM3 KCNB1 UNC13C NPTX1 RIMS2 CAMKK2 KSR2 ANK3 STMN4 VIPR1 DOCK3 CHN1 SYT9 RUNDC3A JPH3 CELF4 MAL2 TUBB4A LANCL1 HHATL WASF1 DLG4 MEG3 PHYHIP AK5 SNCA CYP46A1 MIAT CBLN2 ZC3H12B KRT222
Downregulated	CD44 MMP2 ABCB7 HNMT MCUB STK17A BCHE TRAM1 PHLDA1 GNG12 FCGBP ANXA2P2 FN1 PRRX1 IFI16 SYTL4 KIF4A CD93 TNFRSF19 CDH11 TIMP1 CLIC1 TWSG1 WEE1 CKS2 TRIM24 ECT2 CCDC102B FAM111A ZPR1 NAMPT SPRY1 TRIM4 GBE1 PLSCR1 RBBP8 F2R GUSB LSM8 STXBP4 CDK2 TIMELESS COL4A1 VCAN LAP3 COLGALT1 TGFB1I1 KDELR2 HLA-C TIMP4 ELK3 SERPINA3 ETV1 PARP9 LOC154761 LBR IQGAP2 ANXA1 C1R MSN KDELC2 FAM129A PTPN12 GPX7 PTPRZ1 TMEM45A APOL6 PLP2 DCBLD2 STEAP3 ABCA1 DTX3L DYNLT1 TAP1 JAG1 SMC4 CROT ZFP36L2 EMP1 ZC3HAV1 SLC43A3 LIMA1 GAS2L3 PLA2G4A VIM LGALS3BP SAMD9L PCNA CRISPLD1 TGFBR1 GBP2 NEDD1 CMTM6 RP2 ARAP3 MAP3K1 PRRC1 LAMC1 ANXA5 SNX7 RNF213 PDPN PCDHB7 IKBIP TNC LOXL2 PYGL CFI NUP160 FAM46A CALU CKAP2 PCDHB16 RIT1 TMX1 BAZ1A GBP3 TSPAN6 DDX60L DESI2 DDX58 NES SEMA5A SAMD9 SPARC PDIA4 MTMR11 ANO6 IFI44 NUSAP1 CTSC GNAI3 ARHGAP18 TCTN1 IDH1 MRC2 C21orf62 GBP1

DEGs

Gene names

Upregulated

RALYL GLT1D1 STOX1 GNAL HCN1 GOT1 UNC5A RAB40B BSN PRKCB CA11 KCNA1 SRRM4 CARNS1 ZNF385B CABP1 SLC6A15 RBFOX1 RAB3A CLCN4 CRHBP NEBL HLF IGSF8 SLC39A12 IDS MFSD4A FRMPD4 ATP2B2 RIMBP2 MAP7 C1orf115 OTUD7A RAB11FIP4 NEGR1 MAP1A REPS2 CD200 GAD2 HPCAL4 SST GRM1 ERC2 TRHDE RASGEF1A RIMS1 PHF24 GRIN2A SHANK3 IL1RAPL1 KIF5C GABRA1 UBE2QL1 CACNA2D2 SYN2 GRM3 NEUROD2 KIAA0513 KIAA1644 GNG3 SLC8A2 PPFIA2 PIP4K2A MYT1L LINGO2 IPCEF1 NRG3 OSBPL1A NRGN UNC13A KCNJ3 MOBP NEURL1 NTSR2 CPLX2 FBXL16 RAPGEF5 KCNV1 DGKE KIRREL3 GABRA5 NRXN3 STXBP1 HOOK1 PPP1R1A KCNQ3 ATRNL1 TPPP ATP8A2 ATP2B3 SLIT2 OLFM3 STMN2 ADAM11 SYT4 MAP3K9 YPEL2 SLC6A17 PPIP5K1 HECW1 VAMP2 ROGDI RBFOX3 SYNGR3 GJB6 CACNA1E CNTN4 CHST1 RAP1GAP2 VAMP1 FRRS1L CREG2 CEP170B CPLX1 SYN1 MPPED1 ADCY5 MAL CACNA1B SLC7A14 OLFM1 GABRG1 EPB41L1 KIAA1549L PCLO SV2B FABP3 KCNJ9 SNAP25 ANKS1B SPOCK3 JAKMIP1 SH3GL3 RIMS3 FGFR2 GABRB2 RGS7 NPM2 SVOP ITPR1 KIF5A PKP4 CNTNAP4 PAK3 PPP2R2C RUNDC3B WBSCR17 MAP7D2 CCK DOK6 CSMD1 CDKL2 SLC17A7 S100A1 BRINP1 CELF3 RXFP1 SLC35F3 SULT4A1 KHDRBS2 RAPGEF4 PDE1A OPALIN GPR26 DNAJC6 SRCIN1 ETNPPL SYT1 EDIL3 CNNM1 DLG2 CYP4X1 PACSIN1 TBC1D30 STXBP6 CACNG8 MTURN NELL1 PLCL1 C11orf87 TBR1 ASIC2 CAMK2A FAIM2 GRM5 CACNG3 DDN ST8SIA3 NECAB1 ATP8A1 IQSEC1 LRRC7 LINC00889 CDK5R1 RYR2 FEZF2 NIPAL3 CAMK1D DYNC1I1 ARHGAP44 SLC12A5 RUSC2 PAIP2B NKAIN2 PPP1R16B KIAA0319 CHD5 MYRIP ACSL6 PITPNM3 KCNB1 UNC13C NPTX1 RIMS2 CAMKK2 KSR2 ANK3 STMN4 VIPR1 DOCK3 CHN1 SYT9 RUNDC3A JPH3 CELF4 MAL2 TUBB4A LANCL1 HHATL WASF1 DLG4 MEG3 PHYHIP AK5 SNCA CYP46A1 MIAT CBLN2 ZC3H12B KRT222

Downregulated

CD44 MMP2 ABCB7 HNMT MCUB STK17A BCHE TRAM1 PHLDA1 GNG12 FCGBP ANXA2P2 FN1 PRRX1 IFI16 SYTL4 KIF4A CD93 TNFRSF19 CDH11 TIMP1 CLIC1 TWSG1 WEE1 CKS2 TRIM24 ECT2 CCDC102B FAM111A ZPR1 NAMPT SPRY1 TRIM4 GBE1 PLSCR1 RBBP8 F2R GUSB LSM8 STXBP4 CDK2 TIMELESS COL4A1 VCAN LAP3 COLGALT1 TGFB1I1 KDELR2 HLA-C TIMP4 ELK3 SERPINA3 ETV1 PARP9 LOC154761 LBR IQGAP2 ANXA1 C1R MSN KDELC2 FAM129A PTPN12 GPX7 PTPRZ1 TMEM45A APOL6 PLP2 DCBLD2 STEAP3 ABCA1 DTX3L DYNLT1 TAP1 JAG1 SMC4 CROT ZFP36L2 EMP1 ZC3HAV1 SLC43A3 LIMA1 GAS2L3 PLA2G4A VIM LGALS3BP SAMD9L PCNA CRISPLD1 TGFBR1 GBP2 NEDD1 CMTM6 RP2 ARAP3 MAP3K1 PRRC1 LAMC1 ANXA5 SNX7 RNF213 PDPN PCDHB7 IKBIP TNC LOXL2 PYGL CFI NUP160 FAM46A CALU CKAP2 PCDHB16 RIT1 TMX1 BAZ1A GBP3 TSPAN6 DDX60L DESI2 DDX58 NES SEMA5A SAMD9 SPARC PDIA4 MTMR11 ANO6 IFI44 NUSAP1 CTSC GNAI3 ARHGAP18 TCTN1 IDH1 MRC2 C21orf62 GBP1

Bold print indicates the 35 hub genes. DEGs, differentially expressed genes.