Table IV.
Signaling pathway enrichment analysis of DEGs function in glioblastoma.
| Pathway | Name | Gene count | P-value | Genes |
|---|---|---|---|---|
| A, Upregulated DEG | ||||
| hsa04723 | Retrograde endocannabinoid signaling | 15 | 4.65×10−11 | GABRG1, GABRA1, GABRB2, ADCY5, GABRA5, RIMS1, GRM1, KCNJ3, ITPR1, PRKCB, GRM5, SLC17A7, KCNJ9, GNG3, CACNA1B |
| hsa04020 | Calcium signaling pathway | 14 | 6.51×10−7 | SLC8A2, GRIN2A, GRM1, ITPR1, PRKCB, GRM5, GNAL, ATP2B2, ATP2B3, PDE1A, RYR2, CACNA1E, CAMK2A, CACNA1B |
| hsa04728 | Dopaminergic synapse | 13 | 1.13×10−7 | GNAL, KCNJ9, KIF5A, ADCY5, KIF5C, GRIN2A, GNG3, CAMK2A, KCNJ3, PPP2R2C, ITPR1, PRKCB, CACNA1B |
| hsa04721 | Synaptic vesicle cycle | 12 | 4.98×10−1° | SLC17A7, RAB3A, SYT1, CPLX2, CPLX1, STXBP1, VAMP2, UNC13C, RIMS1, SNAP25, UNC13A, CACNA1B |
| hsa04724 | Glutamatergic synapse | 11 | 2.97×10−7 | SLC17A7, GRM5, GRM3, ADCY5, DLG4, GRIN2A, GNG3, GRM1, KCNJ3, ITPR1, SHANK3, PRKCB |
| hsa04921 | Oxytocin signaling pathway | 12 | 7.64×10−6 | KCNJ9, CACNG8, ADCY5, RYR2, CACNG3, CACNA2D2, CAMK2A, KCNJ3, ITPR1, PRKCB, CAMKK2, CAMK1D |
| hsa05032 | Morphine addiction | 11 | 3.13×10−7 | GABRG1, GABRA1, KCNJ9, GABRB2, ADCY5, PDE1A, GABRA5, GNG3, KCNJ3, PRKCB, CACNA1B |
| hsa04261 | Adrenergic signaling in cardiomyocytes | 11 | 2.35×10−5 | ATP2B2, ATP2B3, CACNG8, ADCY5, PPP1R1A, RYR2, CACNG3, RAPGEF4, CACNA2D2, CAMK2A, PPP2R2C |
| hsa04080 | Neuroactive ligand-receptor interaction | 11 | 3.89×10−3 | GRM5, GABRG1, GRM3, GABRA1, RXFP1, GABRB2, GABRA5, GRIN2A, VIPR1, NTSR2, GRM1 |
| B, Downregulated DEG | ||||
| hsa05200 | Pathways in cancer | 10 | 2.36×10−3 | GNAI3, COL4A1, TGFBR1, CKS2, LAMC1, GNG12, MMP2, CDK2, FN1, F2R |
| hsa04151 | PI3K-Akt signaling pathway | 7 | 4.36×10−2 | COL4A1, TNC, LAMC1, GNG12, CDK2, FN1, F2R |
| hsa05222 | Small cell lung cancer | 5 | 3.68×10−3 | COL4A1, CKS2, LAMC1, CDK2, FN1 |
| hsa04512 | Extracellular matrix-receptor interaction | 5 | 4.01×10−3 | COL4A1, CD44, TNC, LAMC1, FN1 |
| hsa05161 | Hepatitis B | 5 | 2.31×10−2 | DDX58, TGFBR1, MAP3K1, PCNA, CDK2 |
| hsa02010 | ATP-binding cassette transporters | 3 | 4.30×10−2 | TAP1, ABCA1, ABCB7 |
DEGs, differentially expressed genes; PI3K-Akt, phosphatidylinositol 4,5-bisphosphate 3-kinase/RAC-α serine/threonine-protein kinase.