Table III.
Characteristics of sheep and survival outcomes within the study as compared to archive data.
| Sheep | Weight, kg | E. coli dose, CFU/kg | Treatment | Survival time, h | Cumulative NorA administered, µg/kg | NorA dose rate mean AUC, µg/kg |
|---|---|---|---|---|---|---|
| 1 | 68 | 1.08×108 | Placebo (normal saline) | 26 | 26.6 | 13.3a |
| 2 | 74 | 0.94×108 | Placebo (normal saline) | 26 | 0 | |
| 3 | 69 | 1.47×108 | Placebo (normal saline) | 26 | 718.5 | 715 |
| 4 | 58 | 1.62×108 | 10 mg/kg anti-HMGB1 pAbs | 26 | 556.2 | 794b |
| 5 | 71 | 1.50×108 | 10 mg/kg anti-HMGB1 pAbs | 12 | 234.4 | |
| 6 | 76 | 1.58×108 | 10 mg/kg anti-HMGB1 pAbs | 25 | 869.4 | |
| Archive data (n=8; mean ± SD) | 63±8 | 1.08±0.5×108 | Placebo (normal saline) | 25±2.1 | 330±403 | 340 |
a
Applies to sheep 1 and 2
b
applies to sheep 4–6. SD, standard deviation; NorA, noradrenaline; AUC, area under the curve; HMGB1, high mobility group box 1.