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. 2019 Sep 9;18(5):3650–3658. doi: 10.3892/etm.2019.7989

Figure 5.

Figure 5.

MACC1 abolishes the miR-877-mediated inhibition of proliferation and invasion in cervical cancer cells. (A) RT-qPCR was performed to determine the expression of MACC1 mRNA in HeLa and SiHa cells after transfection with pCMV-MACC1 or empty pCMV plasmid. *P<0.05 vs. pCMV. (B) miR-877 mimics were co-transfected with pCMV-MACC1 or empty pCMV plasmids into HeLa and SiHa cells. Following transfection, western blot analysis was performed to examine the protein level of MACC1. (C) Proliferative and (D) invasive capacities of HeLa and SiHa cells co-transfected with miR-877 mimics and pCMV-MACC1 or empty pCMV plasmids were investigated using MTT and transwell cell invasion (magnification, ×200) assays, respectively. *P<0.05 vs. miR-NC. #P<0.05 vs. miR-877 mimics+pCMV. MACC1, metastasis-associated in colon cancer; miR, microRNA; NC, negative control.