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Dose escalation of irinotecan and observed DLTs in patients treated with FOLFIRI plus bevacizumab.
| Irinotecan dose (mg/m2) | *1/*1 patients (DLTs) | *1/*28 patients (DLTs) |
|---|---|---|
| 260 | 10 (1) Grade 3 diarrhea |
10 (2) Grade 3 arrythmia Grade 4 neutropenia |
| 310 | 10 (2) Grade 3 diarrhea x 2 |
10 (4) Grade 3 diarrhea Grade 3 mucositis Grade 4 neutropenia x 2 |
| 370 | 4 (2) Grade 3 nausea/vomiting Grade 5 neutropenic sepsis |
3 (2) Grade 3 diarrhea Grade 4 neutropenia x 2 |
