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. Author manuscript; available in PMC: 2020 Jun 3.
Published in final edited form as: Mol Pharm. 2019 May 15;16(6):2445–2451. doi: 10.1021/acs.molpharmaceut.9b00059

Figure 5.

Figure 5.

High-resolution NIR imaging of the bones after Arthrogen injection: (A) forelimb from Arthrogen-injected mouse (Figure 3) scanned at 24 μm resolution with Li-COR. The high-resolution image shows accumulation in the joints, tendons, and to some extent in the diaphysis of the bone; (B) histological sections of knee and elbow joints of Arthrogen-injected mouse imaged with a NIR microscope. The antibody not only accumulated in the cartilage (C) but also was observed on the endosteal surface (E). B = bone, BM = bone marrow, and M = for muscle. High magnification (bottom) shows accumulation in chondrocytes in the cartilage. Red autofluorescence (rhodamine filter) highlights muscle and bone marrow.