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. 2019 Sep 15;8(9):bio043570. doi: 10.1242/bio.043570

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Downregulation of HE4 inhibited MMPs expression, mesenchymal transition (EMT) and the JAK/STAT3 pathway in ovarian cancer cells. Western blot analyses of MMP-2 and MMP-9 expression in OVCAR3 (A) and C13K (B) cells transfected with sh-HE4 or sh-Ctrl. Western blot analyses of EMT-related proteins (E-cadherin, N-cadherin and Snail) in the transfected OVCAR3 (C) and C13K (D) cells. Western blot analyses of the expression of JAK1, p-JAK1, JAK2, p-JAK2, STAT3 and p-STAT3 in the transfected OVCAR3 (E) and C13K (F) cells. *P<0.05.