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The relative luciferase activity of PXR-mediated UGT1A1 reporter gene (Mean ± SD, n = 3).
| Component | Group | ||
|---|---|---|---|
| Control | RIF (10 μM) | Fold induction | |
| pcDNA3.1(+)-hPXR+pGL3-UGT1A1-Luc+pRL-TK | 0.101 ± 0.013 | 0.311 ± 0.034 | 3.087 ± 0.150 |
| pcDNA3.1(+)+pGL3-UGT1A1+pRL-TK | 0.094 ± 0.007 | 0.137 ± 0.018 | 1.451 ± 0.103 |
| pcDNA3.1(+)-hPXR+pGL3-Basic+pRL-TK | 0.083 ± 0.010 | 0.094 ± 0.014 | 1.135 ± 0.046 |
| pcDNA3.1(+)+pGL3-Basic+pRL-TK | 0.078 ± 0.012 | 0.075 ± 0.010 | 0.967 ± 0.052 |
