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The relative luciferase activity of CAR-mediated UGT1A1 reporter gene (Mean ± SD, n = 3).
| Component | Group | ||
|---|---|---|---|
| Control | CITCO (10 μM) | Fold induction | |
| pcDNA3.1(+)-hCAR+pGL3-UGT1A1-Luc+pRL-TK | 0.099 ± 0.010 | 0.189 ± 0.028 | 1.899 ± 0.093 |
| pcDNA3.1(+)+pGL3-UGT1A1+pRL-TK | 0.096 ± 0.008 | 0.121 ± 0.015 | 1.262 ± 0.047 |
| pcDNA3.1(+)-hCAR+pGL3-Basic+pRL-TK | 0.075 ± 0.007 | 0.086 ± 0.012 | 1.148 ± 0.056 |
