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. 2019 Sep 23;25:7149–7157. doi: 10.12659/MSM.917562

Figure 2.

Figure 2

Silenced UFC1 repressed the biological activity breast cancer in vitro. (A) UFC1 expression in BT-474 and MDA-MB-231 cells transfected with si-UFC1 or si-NC was measured by RT-PCR. (B, C) CCK-8 assay and colony formation assay was conducted to evaluate the cell proliferation of breast cancer cells transfected with si-UFC1 or si-NC. (D, E) Transwell assay assessed the migration and invasion abilities of breast cancer cells transfected with si-UFC1 or si-NC. (F, G) The mRNA and protein expression of apoptotic and EMT related genes in breast cancer cells transfected with si-UFC1 or si-NC. Data are presented as the mean±standard deviation. ** P<0.01, * P<0.05 versus control group. NC – negative control; RT-PCR – real-time polymerase chain reaction; CCK-8 – Cell Counting Kit-8; EMT – epithelial-mesenchymal transition.