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. 2019 Sep 26;25:7218–7227. doi: 10.12659/MSM.916385

Figure 5.

Figure 5

IL-6 and IL-11 modulated STAT3/AKT signaling to regulate adipocyte proliferation in the rat model of polycystic ovary syndrome (PCOS). After the stimulation of adipocytes by IL-6, the relative protein expression of p-STAT3, p-AKT, p-mTOR was detected by Western blot (A). The expression of cell cycle-related proteins, cyclin D1, and CDK4, were detected with Western blot (B). When the STAT3/AKT pathway was blocked, the relative protein expression of pathway and cell cycle-related proteins were examined by Western blot (A, B). Data are presented as the mean ± standard deviation (SD). *** P<0.001 versus the control group. # P<0.05, ## P<0.01 versus the IL-6 group. After the stimulation of adipocytes by IL-11, the relative protein expression of p-STAT3, p-AKT, and p-mTOR were detected with Western blot (C). The expression of cell cycle-related protein, cyclin D1, and CDK4, were detected by Western blot (D). When the STAT3/AKT pathway was blocked, the relative expression of pathway proteins and cell cycle-related proteins was determined by Western blot (C, D). Data are presented as the mean ± standard deviation (SD). *** P<0.001 versus the control group. # P<0.05, ## P<0.01 versus the IL-11 group.