Figure 1. Genomic Landscape of Epithelioid Hemangioendothelioma.

A, Heatmap of the presence (shaded) or absence (white) of known genomic variants based on their shared pathways. While a majority of epithelioid hemangioendothelioma tumors demonstrated a secondary genomic variant (57.1%), few tumors exhibited genomic variants in multiple pathway categories. B, Pathogenic secondary genomic variants were more common in female participants, but the difference was not statistically significant. C, Pathogenic secondary genomic variants were also more common in participants aged 45 years or older at diagnosis, but the difference was not statistically significant.