A, Heatmap of the presence of targetable pathogenic genomic variants (dark blue), targetable variants of unknown significance (VUS) (light blue), or the absence of targetable genomic variants (white) as defined by OncoKB. B, Participants aged 45 years or older at diagnosis were more likely to exhibit a targetable pathogenic genomic variant, but equally likely to demonstrate a targetable VUS compared with participants younger than 45 years at diagnosis.