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. 2019 Sep 20;7(1):e000717. doi: 10.1136/bmjdrc-2019-000717

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Functional profilings in metagenomic predictions by using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) and LDA effect size (LEfSe) analysis. LEfSe barplot showing different abundance of (A) clusters of orthologous groups (COG) functional classifications and (B) COG secondary classifications among control (Con), acarbose (Aca), metformin (Met) and sitagliptin (Sit) groups. They were annotated in evolutionary genealogy of genes: Non-supervised Orthologous Groups (eggNOG) database. Only log linear discriminant analysis (LDA) >3 was shown.