Table 4.
Results of gene cluster analysis and functional distribution growth associated genes and candidate genes
| Cluster name | Growth associated genes | High-confidence candidate genes | Medium-confidence candidate genes | ||||
|---|---|---|---|---|---|---|---|
| No. | Mean fold-enrichment | No. | Mean fold-enrichment | Name | No. | Mean fold-enrichment | |
| Skeletal system development | 996 | 3.2 | 11 | 0.7 | CPZ, EDEM3, FBRS, IFT81, KCND1, PLXNA3, RASA3, SLC7A8, UBR4, USP45, ZFHX3 | 49 | 0.9 |
| Appendage development | 894 | 2.8 | 9 | 0.5 | CPZ, EDEM3, FBRS, IFT81, KCND1, PLXNA3, RASA3, SLC7A8, ZFHX3 | 32 | 1.4 |
| Ciliopathy | 845 | 3.6 | 9 | 1.5 | EDEM3, IFT81, KCND1, PLXNA3, RASA3, SLC7A8, UBR4, USP45, ZFHX3 | 38 | 1.2 |
| Single-organism metabolic process | 740 | 3.7 | 5 | 0.1 | CPZ, EDEM3, KCND1, RASA3, SLC7A8 | 28 | 0.6 |
| Catalytic activity | 721 | 1.7 | 6 | 0.2 | CPZ, EDEM3, RASA3, UBR4, USP45, ZFHX3 | 33 | 1.8 |
| Chemical homeostasis | 629 | 1.9 | 5 | 1.0 | EDEM3, IFT81, KCND1, RASA3, SLC7A8 | 22 | 0.8 |
| Extracellular matrix | 521 | 1.4 | 5 | 1.1 | CPZ, EDEM3, FBRS, PLXNA3, SLC7A8 | 23 | 0.9 |
| Peroxisome biogenesis disorder | 361 | 6.0 | 2 | 0.1 | IFT81, SLC7A8 | 9 | 0.3 |
| Ossification | 284 | 5.6 | 2 | 0.4 | CPZ, EDEM3 | 5 | 1.6 |
| Chromatin binding | 265 | 2.9 | 2 | 0.2 | PLXNA3, ZFHX3 | 12 | 0.8 |
| Proteoglycan metabolic process | 196 | 3.0 | 1 | 0.5 | EDEM3 | 9 | 0.8 |
| Oxidoreductase activity | 190 | 2.7 | 2 | 0.1 | |||
| Congenital hypothyroidism | 184 | 4.2 | |||||
| Diamond-Blackfan anemia | 182 | 3.5 | 5 | 0.4 | |||
| Striated muscle tissue development | 180 | 2.5 | 2 | 0.9 | KCND1, RASA3 | 3 | 0.4 |
| Single-organism carbohydrate catabolic process | 155 | 2.4 | 4 | 1.8 | |||
| DNA repair | 141 | 4.4 | 2 | 0.6 | 4 | 2.5 | |
| Ichthyosis | 139 | 3.9 | 3 | 0.5 | EDEM3 | 2 | 0.6 |
| Head development | 125 | 2.8 | 2 | 2.8 | PLXNA3, ZFHX3 | 2 | 0.3 |
| Hydrolase activity. acting on ester bonds | 116 | 1.9 | 1 | 1.6 | EDEM3 | 1 | 0.1 |
| Behavior | 105 | 2.3 | 1 | 0.3 | ZFHX3 | 1 | 0.2 |
| Sensory organ development | 101 | 4.0 | 2 | 4.3 | |||
| Anatomical structure homeostasis | 99 | 3.1 | |||||
| Sulfur compound metabolic process | 83 | 3.5 | 2 | 0.3 | |||
| Tissue remodeling | 83 | 2.4 | 1 | 0.7 | RASA3 | ||
| Positive regulation of epithelial cell proliferation | 78 | 3.2 | 1 | 1.5 | PLXNA3 | 1 | 0.4 |
| Response to nutrient levels | 63 | 3.4 | 1 | 0.3 | |||
| Bone morphogenesis | 60 | 6.3 | 1 | 2.4 | |||
| Reactive oxygen species metabolic process | 52 | 2.6 | |||||