Fig. 5.

Diffusion tensor imaging reveals changes in brain regions fractional anisotropy (FA), fiber values, and neuronal organization at 12 months after cranial radiotherapy (CRT). (A) FA values in significantly different brain regions as measured in Sham and irradiated animals. 38% of brain regions analyzed showed significant changes after CRT. (B) Overall whole brain fiber number was reduced in CRT animals. (C) Whole brain average fiber length increased after CRT. (D) Global connectomes affected after CRT. Data are shown as 95% permutation distribution confidence interval with triangle indicating the mean difference *P ≤ .05 from permutation testing. Mclust = Model Based Clustering, Trans = Transitivity, Assort = Assortativity, Eglob = Global Efficiency, Eloc = Local Efficiency, Mod = Modularity, and PathL = Path Length. *P ≤ .05, **P ≤ .01.