Table 1.
Clinical characteristics and scanning modalities of studies of Parkinson’s dementia (PDD) versus Parkinson’s without cognitive involvement (PD)
| First author | Modality | N | N | Age | Age PD | MMSE PDD | MMSE PD | H&Y PDD | H&Y PD | UPDRS PDD | UPDRS PD |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PDD | PD | PDD | |||||||||
| Total n = 175 | Total n = 210 | ||||||||||
| (1) Beyerb,c | VBM | 16 | 20 | 73.5 | 72.5 | 19.4 | 28.2 | 3 | 2.4 | ||
| (2) Burtonb | VBM | 26 | 31 | 72.3 | 75.2 | 18.9 | 26.4 | 36.4 | 25.8 | ||
| (3) Geec | VBM | 23 | 10 | 71.6 | 69.4 | 27.3 | 28.9 | 14.4 | 15.3 | ||
| (4) Goldmanb | VBM | 24 | 26 | ||||||||
| (5) Kleinc | FDG-PET | 8 | 9 | 62 | 67 | 21 | 28.4 | 2 | 3 | 24 | 25 |
| (6) Leeb | VBM | 16 | 16 | 69.9 | 68.3 | 19.6 | 27.3 | 2.6 | 1.7 | ||
| (7) Nagano-Saitob,c | VBM | 9 | 17 | 67.3 | 65.4 | 16.1 | 27.9 | 3.3 | 3.1 | ||
| (8) Songb | VBM | 18 | 23 | 72 | 69.1 | 18.1 | 28.6 | 32.1 | 16.9 | ||
| (9) Tangb,c | FDG-PET | 10 | 30 | 61.4 | 61.9 | 23.2 | 28.5 | 2.5 | 1.8 | 30.7 | 23 |
| (10) Xia | VBM | 12 | 12 | 69.3 | 65.6 | 23.4 | 28.1 | 3 | 1.8 | 44 | 14.3 |
| (11) Yongb | FDG-PET | 13 | 16 | 73.4 | 64.2 | 15.4 | 27.3 | 3.2 | 2.1 | ||
| Summary (mean(SD)) | 16 (6) | 19 (8) | 69.3 (4) | 67.8 (4) | 20.2 (4)a | 28.0 (0.8)a | 2.8 (0.5) | 2.3 (0.6) | 30.3 (10) | 20.1 (5) |
Wilcox test shows significant difference between groups (Other comparisons are not significantly different).
Indicates established criteria were used to define PD dementia. Extended neuropsychological testing was used in the remaining studies.
Indicates the study matched PDD and PD groups for motor stage.
FDG-PET, fluorodeoxyglucose positron emission tomography; H&Y, Hoehn and Yahr; MMSE, mini-mental state examination; PDD, Parkinson’s disease dementia; SPECT, single photon emission computed tomography; UPDRS, Unified Parkinson’s disease rating scale score (part III, motor); VBM, voxel-based morphometry.