Table 2.

Summary of profile attributes

	Information Enthusiasts	Concerned Individuals	Contemplators	Individuals of Advanced Life Stage	Reassurance Seekers
Attitude toward IR	Enthusiastic Sense of agency related to learning IR Confident in their decisions	Hesitant Reluctant to learn IR or pursue GS	Recognize potential value Discerning about the limitations Engage in extensive deliberation	Primarily consider impacts for family members Consider how their decisions would have differed at an earlier life stage	Expect not to carry IR Hope for reassurance Possible misunderstanding of IR
Concerns about IR	Limited concerns	Emotional and psychological impacts	Uncertainty related to IR	Passing disease risks to family members	Receiving multiple IR
		Limitations of the technology		How their future illness may impact family
Self-Definition	A “planner”	“Anxious”	Not stated	Altruistic “Experienced”	Not stated
Perceived utility of IR	Medical actions, lifestyle changes Planning for self and family Sharing results with family Seeking further information “Knowledge is power”	Medical actions Weigh utility against potential negative impacts Low perceived utility overall	Medical actions Planning	Planning, particularly for family members Planning to maintain quality of life	Reassurance about disease risk if they do not carry IR Medical actions
Sample category selection	✔Category 1: Medically actionable ✔Category 2: Common Disease Risks ✔Category 3: Rare Genetic Diseases ✔Category 4: Early-Onset Brain Diseases ✔Category 5: Carrier Status	x Category 1: Medically actionable x Category 2: Common Disease Risks x Category 3: Rare Genetic Diseases x Category 4: Early-Onset Brain Diseases x Category 5: Carrier Status	✔Category 1: Medically actionable ✔Category 2: Common Disease Risks ✔Category 3: Rare Genetic Diseases ? Category 4: Early-Onset Brain Diseases ✔Category 5: Carrier Status	✔Category 1: Medically actionable ✔Category 2: Common Disease Risks ✔Category 3: Rare Genetic Diseases ✔Category 4: Early-Onset Brain Diseases ? Category 5: Carrier Status	✔Category 1: Medically actionable ✔Category 2: Common Disease Risks ✔Category 3: Rare Genetic Diseases ✔Category 4: Early-Onset Brain Diseases x Category 5: Carrier Status
Contextual factors	Typically middle-aged Typically have children	Past distressing experience with genetic testing, or profound health experience	Tend to be younger than other participants	Lived experience with disease Typically have adult children	Expectations for IR are shaped by their previous negative genetic test result
Illustrative quote	“I'm very much for planning and being prepared. And, also if there are things I'm doing that I should be doing differently that could make a difference in the end result kind of thing, then I would want to know what those things were more specifically.” – SB03	“I really feel like the emotional component is the one that I was struggling with the most.  Because, I do not believe I really fully understand what I can handle and what I can't handle.” – SB27	“It's a tricky thing […] I absolutely want to be informed […] Then at the same time, once you know something, you can't really un-know it.” – MK42	“I don't want to be a burden on my kids […] I would want to do everything ahead of time […] I would want them to see me in a good light. I don't want them to remember me in a sick state.” – SB31	“I want to participate in any learning possible and because I already had a negative one, let’s just do it and get the rest of it, and it’ll hopefully be negative, too. And then I can rest easy and sleep well.” – MK40