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. 2019 Jun 24;27(9):1326–1340. doi: 10.1038/s41431-019-0435-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overview of the imprinted region 15q11q13. Schematic overview of the genes located within the PWS and AS critical region on chromosome 15q11q13. Upper part - paternal allele (pat), lower part - maternal allele (mat). Blue boxes/vertical lines represent paternally expressed genes/snoRNAs; red box, maternally expressed gene; black boxes, biallelically expressed genes and arrow heads represent the orientation of transcription. IC imprinting centre, BP common breakpoint cluster region, cen centromeric, tel telomeric. Modified from Ramsden et al. [1]