Table 1.
Frequency of AZFc rearrangements and DAZ dosage alterations in TGCT patients (reported in subgroups based on histotypes and total sperm count) and in controls (reported in subgroups based on total sperm count)
| gr/gr deletion | Other partial AZFc deletionsa | Partial AZFc duplications | DAZ dosage alteration | ||
|---|---|---|---|---|---|
| TGCT | Total | 14/497 (2.8%) | 5/497 (1.0%) | 22/478 (4.6%) | 51/497 (10.3%) |
| NZ | 9/268 (3.4%) | 3/268 (1.1%) | 9/256 (3.5%) | 28/268 (10.4%) | |
| NNZ | 5/229 (2.2%) | 2/229 (0.9%) | 13/222 (5.9%) | 23/229 (10.0%) | |
| Seminoma | 11/353 (3.1%) | 4/353 (1.1%) | 16/338 (4.7%) | 38/353 (10.8%) | |
| Non-seminoma | 3/144 (2.1%) | 1/144 (0.7%) | 6/140 (4.3%) | 13/144 (9.0%) | |
| Seminoma NZ | 8/196 (4.1%) | 2/196 (1.0%) | 7/186 (3.8%) | 23/196 (11.7%) | |
| Seminoma NNZ | 3/157 (1.9%) | 2/157 (1.3%) | 9/152 (5.9%) | 15/157 (9.5%) | |
| Non-Seminoma NZ | 1/72 (1.4%) | 1/72 (1.4%) | 2/70 (2.9%) | 5/72 (6.9%) | |
| Non-Seminoma NNZ | 2/72 (2.8%) | 0/72 (0.0%) | 4/70 (5.7%) | 8/72 (11.1%) | |
| Controls | Total | 40/2030 (2.0%) | 11/2030 (0.5%) | 51/1373 (3.7%) | 111/1424 (7.8%) |
| NZ | 10/1068 (0.9%) | 2/1068 (0.2%) | 27/756 (3.6%) | 46/768 (6.0%) | |
| NNZ | 30/962 (3.1%) | 9/962 (0.9%) | 24/617 (3.9%) | 65/656 (9.9%) |
The columns report the number of subject observed with rearrangements/total subject patients and the percentage in parenthesis
NZ normozoospermic, NNZ non-normozoospermic
aOther partial AZFc deletions refers to b2/b3, b1/b3, and atypical deletion