Table 4.
Comparison of the frequency of gr/gr deletion, partial AZFc duplications and DAZ dosage alteration between TGCT patients and control subjects (total and subgroups based on total sperm count: normozoospermia vs. non-normozoospermia)
| AZFc region rearrangements | TGCT (n = 497) | Controls (n = 2030a) | p-value (OR, 95% CI) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (%) | NZ (%) | NNZ (%) | Total (%) | NZ (%) | NNZ (%) | p1 | p2 | p3 | p4 | p5 | p6 | p7 | p8 | p9 | |
| Partial AZFc deletions | 3.8 | 4.5 | 3.1 | 2.5 | 1.1 | 4.1 | 0.078 | 0.001 (3.5, 1.7–7.3) | 0.477 | 0.056 | 0.001 (4.1, 1.8–9.3) | 0.435 | 0.373 | 0.036 (2.8, 1.1–7.1) | 0.314 |
| gr/gr deletion | 2.8 | 3.4 | 2.2 | 2.0 | 0.9 | 3.1 | 0.159 | 0.006 (3.1, 1.4–7.0) | 0.444 | 0.109 | 0.006 (3.7, 1.5–9.1) | 0.486 | 0.486 | 0.108 | 0.308 |
| Partial AZFc duplications | 4.6 | 3.5 | 5.9 | 3.7 | 3.6 | 3.9 | 0.232 | 0.224 | 0.332 | 0.526 | 0.572 | 0.483 | 0.097 | 0.097 | 0.151 |
| DAZ dosage alteration | 10.3 | 10.4 | 10.0 | 7.8 | 6.0 | 9.9 | 0.056 | 0.004 (1.8, 1.2–2.7) | 0.459 | 0.094 | 0.013 (1.8, 1.1–3.0) | 0.444 | 0.152 | 0.027 (1.7, 1.0–3.0) | 0.521 |
NZ normozoospermic, NNZ non-normozoospermic
p1 = total TGCT vs. total controls; p2 = total TGCT vs. NZ controls; p3 = total TGCT vs. NNZ controls; p4 = NZ TGCT vs. total controls; p5 = NZ TGCT vs. NZ controls; p6 = NZ TGCT vs. NNZ controls; p7 = NNZ TGCT vs. total controls; p8 = NNZ TGCT vs. NZ control; p9 = NNZ TGCT vs. NNZ control
p-value of 0.025 was considered statistically significant, after Bonferroni correction, significant values are reported in bold
aAnalysis for partial AZFc duplications were performed in 1424 subjects