Table 2.
ER-phagy–associated proteins and their functions.
| Organisms | Proteins | Functional annotation | References |
|---|---|---|---|
| Yeast (Sc) | Atg39 | Essential for cell survival under nitrogen starvation, receptors for perinuclear ER. | Mochida et al., 2015 |
| Atg40 | Functional counterpart of FAM134B, receptors for peripheral ER, interact with the Atg1 complex. | ||
| Mammal (Hs) | Lnp1 | Stabilizes rearrangements of the ER network. | Chen et al., 2018 |
| FAM134B | Reticulon-like protein present on sheet ER. | Khaminets et al., 2015 | |
| Calnexin | Co-receptor for ER luminal misfolded procollagens Direct interaction with FAM134B. |
Forrester et al., 2019 | |
| RTN3 | Tubular ER-resident protein. | Grumati et al., 2017 | |
| SEC62 | ER translocon. | Fumagalli et al., 2016 | |
| CCPG1 | A vertebrate-specific protein can interact not only with LC3/GABARAP but also with FIP200; required for efficient degradation of tubular ER. | Smith and Wilkinson, 2018 | |
| Plants (At) | IRE1b | Key regulator in ER stress responses. Nucleotide binding activity of IRE1b is required for ER stress–mediated autophagy. |
Liu et al., 2012 Bao et al., 2018 |
| PDR2, LPR1 | PDR2 is a single ER-resident P5-type ATPase (AtP5A), which controls the secretion and activity of LPR, the cell wall–targeted ferroxidase. Pi deprivation–induced ER stress–activated autophagy requires the LPR1–PDR2 module. | Naumann et al., 2019 | |
| NAP1 | A component of the SCAR/WAVE complex, required for ARP2/3-mediated actin nucleation. nap1 mutant has reduced autophagosomes and is more sensitive to nitrogen starvation and salt stress. |
Wang et al., 2016 |
FAM134B, family with sequence similarity 134 member B; Lnp1, lunapark1; RTN3, reticulon 3; CCPG1, cell-cycle progression gene 1; LC3, microtubule-associated protein light chain 3; GABARAP, gamma-aminobutyric acid receptor–associated protein; FIP200, 200 kDa FAK family kinase-interacting protein; PDR2, phosphate deficiency response 2; AtP5A, P5-type ATPase; LPR1, low phosphate response 1; Pi, phosphate (inorganic); NAP1, nck-associated protein 1; SCAR, suppressor of cAMP receptor; WAVE, Wiskott–Aldrich syndrome (WASP) family verprolin homologous; Arp2/3, actin-related proteins 2/3.