Table 3.

Descriptive characteristics of the 1065 Danish persons with NF1 and the 8791 NF1-free persons, born 1965–2000, graduated from grade 9 in Denmark 1981–2015

	NF1 cohort				NF1-free cohort
	N	%	Grad.	Person-years	N	%	Grad.	Person-years
Total	1,065		932	2,734	8,791		7,962	19,274
Gender
Male	529	50	454	1,416	4,426	50	3,897	10,216
Female	536	50	478	1,318	4,365	50	4,065	9,058
Pearson χ2(1) = 0.17 Pr. = 0.68
Birth year
1965–1969	107	10	102	260	960	11	916	2,187
1970–1974	151	14	144	341	1,248	14	1,208	2,687
1975–1979	136	13	128	351	1,025	12	996	2,278
1980–1984	133	13	119	412	907	10	869	2,082
1985–1989	128	12	115	384	934	10	890	2,249
1990–1994	164	15	153	465	1,375	16	1,314	3,330
1995–2002	246	23	171	520	2,342	27	1,769	4,461
Pearson χ2 (6) = 12.20 Pr = 0.058
Mother’s education
Short	343	32	298	891	2,234	25	2,003	5,381
Medium	502	47	439	1,317	4,273	49	3,914	9,199
Long	189	18	168	434	2,097	24	1,896	4,211
Missing	31	3			187	2
Pearson χ2 (3) = 35.11 Pr = 0.000
Cancera
Yes	57	5	50	148	49	1	48	102
Pearson χ2 (1) = 205.26 Pr = 0.000
Diseases of bone, joints and soft tissueb
	76	7	70	192	137	2	126	306
Pearson χ2 (1) = 139.77 Pr = 0.000
Diseases of nervous systemc
	155	15	126	479	468	5	406	1,136
Pearson χ2 (1) = 136.68 Pr = 0.000
Diseases of circulatory systemd
	25	2	19	62	34	0	32	72
Pearson χ2 (1) = 61.37 Pr = 0.000
Other medical diseasese
	533	50	461	1,442	3,071	35	2,746	6,938
Pearson χ2 (1) = 93.54 Pr = 0.000
Anxietyf
	7	1	5	17	48	1	42	123
Pearson χ2 (1) = 0.21 Pr = 0.645
Autismg
	23	2	15	92	92	1	75	295
Pearson χ2 (1) = 10.21 Pr = 0.001
ADHDh
	50	5	39	114	114	1	94	324
Pearson χ2 (1) = 67.03 Pr = 0.000
Autism/ADHD
	69	7	50	198	199	2	163	601
Pearson χ2 (1) = 63.81 Pr = 0.000
Depression and other psychiatric diseasesi
	172	16	128	499	497	6	405	1,432
Pearson χ2 (1) = 165.42 Pr = 0.000
Age at graduation (years)
14–15			10	1,047			46	8,622
15–15.5			44	501			579	4,090
15.5–16			278	413			3,189	3,074
16–16.5			348	235			3,250	1,260
16.5–17			170	110			703	345
17–18			77	83			186	315
18–20			5	346			9	1,568

^aCancer; malignant (ICD-10): C00-C43, C46-C96, B21.0, D30.1-D30.9, D32-D33, D35.2-D35.4, D41.4, D42-D43, D44.3-D44.5, benign (ICD-8): 210–221, 223.0, 224, 225.5–225.6, 226.0–226.1, 226.4–228

^bDiseases of bone, joints soft tissue (ICD-8): 720–738, 274, 710–718

^cDiseases of nervous system (ICD-8): 290, 320–324, 340–342, 344–347, 349–358, 360–389

^dDiseases of circulatory system (ICD-8): 390–398, 400–404, 410–414, 420–438, 440–448, 450–458

^eOther medical diseases (ICD-8): 000–136, 240–242, 244–269, 275.4–276, 278–279, 606, 626–628, 280–281, 283–289, 460–519, 520–543, 550–577, 580–605, 607–625, 629, 700–709, 680–686, 690–698, 274, 710–718, 720–738

^fAnxiety (ICD-10): F41, Depression (ICD-10): F32

^gAutism (ICD-10): F84

^hADHD (ICD-10): F90

ⁱDepression and other psychiatric disease (ICD-10): F01–99, excluding F41, F84, F90