Fig. 1.
Establishment of CRCs from 4 bladder PDX tumors. a Clinical characteristics of the 3 donor patients. Four PDXs were developed from the 3 advanced bladder cancer patients. BL0269_GDC-R was developed from a BL0269 PDX after with the host mouse was treated with a PI3K inhibitor GDC-0941 and developed resistant PDXs. b Representative images of CRCs grown (arrow) in co-culture with irradiated 3T3-J2 mouse fibroblasts. c STR analysis of the PDX CRCs after 3 passages in CR culture. Electropherograms are shown in Additional files 1–4: Figures S1–S4.