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. Author manuscript; available in PMC: 2020 May 25.
Published in final edited form as: J Ind Eng Chem. 2019 Jan 28;73:8–18. doi: 10.1016/j.jiec.2019.01.021

Figure 8.

Figure 8.

Delivery of siRNA into glioblastoma using SNA. (a) Accumulation of gold nanoparticles in the brain and glioblastoma region. (b) Schematic illustration of Gd(III)-modified SNA for MR imaging. (c) Accumulation of SNA by crossing the BBB monitored by MRI section, H&E staining, and 3D reconstituted MRI. (d) LA-ICP-MS mapping of Gd(III)-modified SNA in the brain. (e) Confocal microscopic image of coronal brain sections derived from normal and glioblastoma-bearing mice upon injection of Cy-5 modified SNA. Reproduced with permission [98]. Copyright 2013, AAAS.