Table 4.
Mediation analysis of CML and CEL with all-cause mortality through hs-CRP, thiols, and sVCAM-1
| Predictor | Potential Mediator | Effect (Path)a | Coefficient (95% CI, bc)b | Proportion Mediatedc (95% CI, bc)b |
|---|---|---|---|---|
| CML | hs-CRP | Indirect effect (ab path) | −0.01 (–0.03 to 0.002) | Not mediated |
| Total effect (ab+c’ path) | 0.11 (0.02 to 0.21) | |||
| Thiol | Indirect effect (ab path) | 0.03 (0.009 to 0.05) | 22% (3% to 89%) | |
| Total effect (ab+c’ path) | 0.12 (0.02 to 0.22) | |||
| sVCAM-1 | Indirect effect (ab path) | 0.03 (0.005 to 0.08) | 26% (4% to 74%) | |
| Total effect (ab+c’ path) | 0.11 (0.01 to 0.20) | |||
| CEL | hs-CRP | Indirect effect (ab path) | −0.006 (–0.02 to 0.006) | Not mediated |
| Total effect (ab+c’ path) | 0.14 (0.06 to 0.23) | |||
| Thiol | Indirect effect (ab path) | 0.02 (0.003 to 0.04) | 9% (1% to 27%) | |
| Total effect (ab+c’ path) | 0.16 (0.07 to 0.25) | |||
| sVCAM-1 | Indirect effect (ab path) | 0.03 (0.01 to 0.07) | 21% (7% to 45%) | |
| Total effect (ab+c’ path) | 0.14 (0.06 to 0.23) |
CML, Nε-(Carboxymethyl)lysine; CEL, Nε-(Carboxyethyl)lysine; hs-CRP, high sensitivity C-reactive protein; sVCAM-1, soluble vascular cell adhesion molecule-1; 95% CI, 95% confidence interval; Bc, bias corrected.
The coefficients of the indirect ab path and the total ab+c’ path are standardized for the SD of the potential mediators, circulating CML and CEL concentrations and all-cause mortality.
95% CIs for the indirect and total effects, and proportion mediated were bias-corrected after running 2000 bootstrap samples.
The size of the significant mediated effect is calculated as the standardized indirect effect divided by the standardized total effect multiplied by 100.