Summary of clinical features of patients with 6q22.1-q22.31 deletions
	Patient 1	Patient 2	Patient 3	Patient 4
Age, sex	5 years., male	4 years., male	1 month, female	3 months, female
Developmental delay	+	+	+	−
Seizures	Only epileptiform activity on EEG	+	−	−
Craniosynostosis	−	−	+	+
Brain malformation	−	+	−	+
Dysmorphic facial features	+	+	+	+
Size, Mb	9,8	7,9	13,9	11,9
Molecular karyotype	arr[hg19] 6q22.1q22.31(114650304_124411267)x1	arr[hg19] 6q22.1q22.31(117939083_125843984)x1	arr[hg19] 6q21q22.31(109428325_123335803)x1	arr[hg19] 6q21q22.31(113684116_125569047)x1