Fig. 1.

Pedigree of the affected Malinois family (drawn with the kinship2 package in RStudio [35]). Numbers correspond to the investigated dogs described in Supplementary Information File 2. Dog X was killed because of the same symptoms but no video footage nor blood sample was available to confirm the diagnosis. Whole-exome sequencing was performed on dogs marked with a degree sign. The SLC12A6 NC_006612.3(XM_014109414.2):c.178_181delinsCATCTCACTCAT genotype is shown as Wt/Wt, Wt/Vt, or Vt/Vt. Dogs with an asterisk carry 1 allele of the NC_006620.3:g.22141027_22141028insC variant [13]