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Dock3 GEF activity. Lysates from Cos-7 cells transfected with the indicated plasmids were subjected to the pull-down assay for measurement of Rac1 activity using the GST-CRIB fusion protein. Expression of Dock3, total Rac1, and activated Rac1 were detected by immunoblot analysis (left panel). The level of activated Rac1 was quantified and shown in the histogram (right panel). The data are presented as means ± S.E.M. of four samples. *P < 0.05
