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. 2019 Sep 27;10:885. doi: 10.3389/fgene.2019.00885

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Copyright © 2019 Duforestel, Nadaradjane, Bougras-Cartron, Briand, Olivier, Frenel, Vallette, Lelièvre and Cartron

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The combination of glyphosate exposure and miR-182 overexpression is tumorigenic for MCF10A cells in a two-factor hit model. (A) The timetable illustrates the experiment design. Explanations for color-coded days are located in corresponding color rectangles underneath the timeline. (B and C) Four mice were injected per condition. miRCury LNA miR mimics and siRNA for TET3 were used to overexpress miRs or siRNA in MCF10A cells. Mice were euthanized 21 days after the injection of cells, and the tumors were resected. The pictures show the resected tumors.