Table 3.
Rare Isocitrate Dehydrogenase (IDH) Mutations and Probability of Predicting IDH Mutation with Raman Spectroscopy (GB = glioblastoma)
| Tissue preparation | Histology/grade | Rare IDH mutation confirmed with targeted genetic sequencing | Probability of predicting IDH mutation with Raman model |
|---|---|---|---|
| Fresh tissue | Astrocytoma (GB) IV | IDH1 394T | 0.95 |
| Astrocytoma (GB) IV | IDH2 G515T | 0.92 | |
| Astrocytoma II | IDH2 G515A | 0.87 | |
| Cryosections | Astrocytoma II | IDH1 R132C | 0.92 |
| Astrocytoma II | IDH1 R132C | 0.96 | |
| Astrocytoma (GB) IV | IDH1 R394T | 0.61 | |
| Oligodengroglioma II | IDH2 R172K | 0.93 | |
| Oligodengroglioma II | IDH2 R172K | 0.78 | |
| Astrocytoma III | IDH1 R132C | 0.77 | |
| FFPE sections | Astrocytoma (GB) IV | IDH1 R132C | 0.57 |
| Astrocytoma (GB) IV | IDH1 R132G | 0.82 | |
| Oligodengroglioma II | IDH2 R172K | 0.82 | |
| Oligodengroglioma III | IDH2 R172W | 0.89 |