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. 2019 Sep 5;44(5):1753–1770. doi: 10.3892/ijmm.2019.4332

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PPI network, significant module network, and the hub genes. (A) The PPI network showing the intricate relationships between DEGs. (B) The significant module network selected based on the PPI network. (C) A total of 10 genes (CLU, SOCS3, PRSS23, BMP4, TLR4, CYR61, IL6, CALU, TNC and SCG2) were identified as hub genes with degrees ≥10. PPI, protein-protein interaction; DEGs, differentially expressed genes. IL6, interleukin-6; BMP4, bone morphogenetic protein 4; CALU, calumenin; CLU, clusterin; CYR61, cysteine rich angiogenic inducer 61; PRSS23, serine protease 23; SCG2, secretogranin II; SOCS3, suppressor of cytokine signaling 3; TLR4, Toll-like receptor 4; TNC, tenascin C.