Table II.

Receiver operator characteristic curve analysis of hub gene expression for SSc.

Gene symbol	SSc
	AUC	P-value	95% CI	ODT
IL6	0.970	0.000c	0.889-1.000	40.502
TLR4	0.822	0.002b	0.733-1.000	69.185
CYR61	0.878	0.000c	0.867-0.889	584.379
TNC	0.852	0.001b	0.722-0.933	1128.397
SCG2	0.856	0.001b	0.800-0.833	47.679
SOCS3	0.759	0.011a	0.667-0.833	28.669
BMP4	0.744	0.017a	0.533-0.889	112.929
CALU	0.744	0.017a	0.733-1.000	510.164
PRSS23	0.996	0.000c	0.944-1.000	910.976
CLU	0.863	0.000c	0.733-0.944	1308.718

^a-cSignificant variables.

^aP<0.05,

^bP<0.01,

^cP<0.001. AUC, area under curve; ^max the maximum of AUC; ODT, optimal diagnostic threshold; SSc, systemic sclerosis; CI, confidence interval; IL6, interleukin‑6; BMP4, bone morphogenetic protein 4; CALU, calumenin; CLU, clusterin; CYR61, cysteine rich angiogenic inducer 61; PRSS23, serine protease 23; SCG2, secretogranin II; SOCS3, suppressor of cytokine signaling 3; TLR4, Toll-like receptor 4; TNC, tenascin C.