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. 2019 Sep 10;44(5):1781–1788. doi: 10.3892/ijmm.2019.4335

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Cx43 silencing on podocyte autophagy. The rats were injected with STZ, followed by placement of an osmotic minipump with which to infuse Cx43 siRNA (50 μM) or NC-siRNA (50 μM) for 28 days. (A) Kidney tissue sections were subjected to histological examination via immunohistochem-istry (Cx43, magnification, x400). (B and C) Western blot analysis of LC3, p62 and Cx43. The data are presented after normalization to GAPDH expression and quantified as mean ± standard error of the mean; n=3 per group; ^#P<0.05 vs. control group; ^*P<0.05 vs. DN group (Bonferroni's correction). STZ, streptozocin; DN, diabetic nephropathy.