Table III.
Pathway analysis of metabolite changes in BCaa.
| KEGG pathway | Total | Hits | P-value |
|---|---|---|---|
| Glutathione metabolism | 38 | 3 | 1.55E-02 |
| Purine metabolism | 92 | 4 | 3.86E-02 |
| Thiamine metabolism | 24 | 2 | 4.40E-02 |
| Nitrogen metabolism | 39 | 2 | 1.04E-01 |
| Primary bile acid biosynthesis | 47 | 2 | 1.41E-01 |
| Fructose and mannose metabolism | 48 | 2 | 1.46E-01 |
| Cysteine and methionine metabolism | 56 | 2 | 1.86E-01 |
| Cyanoamino acid metabolism | 16 | 1 | 2.04E-01 |
| Pyrimidine metabolism | 60 | 2 | 2.07E-01 |
| Taurine and hypotaurine metabolism | 20 | 1 | 2.48E-01 |
| Retinol metabolism | 22 | 1 | 2.70E-01 |
| Ether lipid metabolism | 23 | 1 | 2.80E-01 |
| Aminoacyl-tRNA biosynthesis | 75 | 2 | 2.86E-01 |
| Alanine, aspartate and glutamate metabolism | 24 | 1 | 2.90E-01 |
| Sphingolipid metabolism | 25 | 1 | 3.01E-01 |
| Pantothenate and CoA biosynthesis | 27 | 1 | 3.20E-01 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 27 | 1 | 3.20E-01 |
| Methane metabolism | 34 | 1 | 3.86E-01 |
| Glycerophospholipid metabolism | 39 | 1 | 4.28E-01 |
| Porphyrin and chlorophyll metabolism | 104 | 2 | 4.36E-01 |
| Galactose metabolism | 41 | 1 | 4.45E-01 |
| Histidine metabolism | 44 | 1 | 4.68E-01 |
| Phenylalanine metabolism | 45 | 1 | 4.76E-01 |
| Lysine degradation | 47 | 1 | 4.91E-01 |
| Glycine, serine and threonine metabolism | 48 | 1 | 4.98E-01 |
| Fatty acid metabolism | 50 | 1 | 5.13E-01 |
| Amino sugar and nucleotide sugar metabolism | 88 | 1 | 7.21E-01 |
| Steroid hormone biosynthesis | 99 | 1 | 7.63E-01 |
a
The analysis was conducted by the module of pathway analysis of MetaboAnalyst 4.0. BCa, bladder cancer; KEGG, Kyoto Encyclopedia of Genes and Genomes.