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. 2019 Sep 17;44(5):1932–1942. doi: 10.3892/ijmm.2019.4342

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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STVNa prevents SR calcium depletion induced by Iso. Caffeine induced Ca²⁺ transients indicating Ca²⁺ content of SR. Experiments were carried out using cardiomyocytes isolated from rats. Representative traces of Fluo-4 fluorescence following application of (A) caffeine with the (B) corresponding graph. Each bar represents the mean ± standard error of the mean. ^*P<0.05 vs. the Con group; ^#P<0.05 vs. Iso group (n=6 for each). Iso, isoprenaline; STVNa, isosteviol sodium; Con, control; SR, sarcoplasmic reticulum.