TABLE 2.

Grading financial toxicity as an adverse event

	Common Terminology Criteria for Adverse Events (CTCAE) v5.030	Prototype for Grading Financial Toxicity29
Grade 1	Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated	Lifestyle modification (deferral of large purchases or reduced spending on vacation and leisure activities) because of medical expenditure; use of charity grants/fundraising/copayment program mechanisms to meet costs of care
Grade 2	Moderate; minimal, local, or noninvasive intervention indicated; limiting age-appropriate instrumental activities of daily living	Temporary loss of employment resulting from medical treatment; need to sell stocks/investments for medical expenditure; use of savings accounts, disability income, or retirement funds for medical expenditure
Grade 3	Severe or medically significant but not immediately life threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care activities of daily living	Need to mortgage/refinance home to pay medical bills; permanent loss of job as a result of medical treatment; current debts > household income; inability to pay for necessities such as food or utilities
Grade 4	Life-threatening consequences; urgent intervention indicated	Need to sell home to pay for medical bills; declaration of bankruptcy because of medical treatment; need to stop treatment because of financial burden; consideration of suicide because of financial burden of care
Grade 5	Death related to adverse event