. 2019 Oct 4;16(10):e1002891. doi: 10.1371/journal.pmed.1002891

Table 3. Proportion of confirmed doses, WOT versus DOT. ITT analysis. Confirmed dose defined as 1 or more tablets detected or witnessed.

	WOT (N = 41)	DOT (N = 20)	Difference (95% CI)	OR (95% CI)	p-Value
Proportion confirmed (95% CI)^a	0.929 (0.887, 0.960)	0.631 (0.583, 0.669)	0.298 (0.243, 0.355)	7.69 (4.51, 14.48)	<0.001^b
≥90% confirmed doses, N (%)^c	32 (78.0)	0 (0.0)	(64.8, 87.0)^a		<0.001^d
Total doses confirmed (yes/no)	3,738/284	1,202/702

^aBootstrap estimate.

^bWilcoxon rank–sum test.

^cPatients who have 90% or more of days with confirmed doses.

^dFisher’s exact test.

Abbreviations: CI, confidence interval; DOT, directly observed therapy; ITT, intent to treat; OR, odds ratio; WOT, wirelessly observed therapy.