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. 2019 Aug 22;4(16):e129954. doi: 10.1172/jci.insight.129954

Figure 1. Exogenous glucagon stimulates insulin secretion and lowers glycemia.

Figure 1

Low-dose (20 μg/kg) glucagon (A) increases glycemia and (B) does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) glucagon (C) lowers glycemia compared with PBS control and (D) stimulates insulin secretion in ambient-fed mice. *P < 0.05 vs. PBS control (A and C) or 0-minute value (D); values are mean ± SEM. Statistical tests: Student’s paired t test (B and D) and 2-way ANOVA (A and C). iAUC, incremental AUC.