Skip to main content
. 2019 Aug 22;4(16):e129719. doi: 10.1172/jci.insight.129719

Figure 1. TFEB overexpression prevents mutant A53T–α-syn toxicity in a rat model of Parkinson’s disease.

Figure 1

(A) TFEB overexpression restores the use of left paw in the cylinder test. (B) TFEB overexpression alleviates amphetamine-induced rotation behavior (1 mg/kg). (C) TFEB overexpression prevents α-syn–induced dopaminergic degeneration. Left lane and upper plot: representative images and quantification of striatal tyrosine hydroxylase (TH) staining. Right lane and lower plot: representative images of mesencephalic section of TH staining and stereological counting of TH-positive cells in the substantia nigra (SN). Inverted green fire blue lookup table was used to enhance visualization of the lesion. (D) Representative images and surface quantification of human α-syn staining in the SN. Scale bar: 50 μm. (E) Representative images of Serine129-phosphorylated α-syn in the SN. Scale bar: 500 μm. Data represent mean ± SEM. Comparisons were made using 1-way ANOVA and Bonferroni’s correction for multiple comparison, n = 7–8 per group. *P < 0.05 vs. sham-injected animals. $P < 0.05 vs. hSynA53T-injected animals.