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. 2019 Aug 22;4(16):e129719. doi: 10.1172/jci.insight.129719

Figure 4. Specific oligodendroglial TFEB-targeted overexpression attenuates dopaminergic neurodegeneration in a MSA mouse model.

Figure 4

(A) Representative images of TH staining in the SN of control, CMVie/hSyn-mTFEB–injected, and MBP-mTFEB–injected WT and PLP mice. Scale bar: 500 μm. (B) Number of TH- and Nissl-positive neurons counted by stereology in the SN of control, CMVie/hSyn-mTFEB–injected, and MBP-mTFEB–injected WT and PLP mice. (C) Representative images of TH staining into the striatum of control, CMVie/hSyn-mTFEB–injected, and MBP-mTFEB–injected WT and PLP mice. Scale bar: 500 μm. (D) Dot plot of mean gray-scale values of striatal TH immunoreactivity measured by optical density in the striatum of control, CMVie/hSyn-mTFEB–injected, and MBP-mTFEB–injected WT and PLP mice. n = 5 per group. White bars, control; blue bars, CMVie/hSyn-mTFEB-HA; green bars, MBP-mTFEB-3×Flag. Data represent mean ± SEM. Comparisons were made using 2-way ANOVA and Tukey’s correction for multiple comparisons. *P < 0.05 compared with WT mice. #P < 0.05 compared with PLP control mice. $P < 0.05 compared with CMVie/hSyn-mTFEB injected PLP mice.