Figure 7. P2Y₁₂ and A2b receptors are drug targets for the treatment of lower urinary tract symptoms.

(A and B) Representative images of voiding spot assay (VSA) filter papers from wild-type mice before (A) and after (B) Bay 60-6583 treatment. (C–E) Quantitated VSA data (n = 26). (F and G) Representative images of VSA filter papers from P2Y₁₂-KO mice before (F) and after (G) PSB1115 treatment. (H–J) Quantitated VSA data (n = 8). (K and L) Representative images of VSA filter papers from A2b-KO mice before (K) and after (L) Ticagrelor treatment. (M–O) Quantitated VSA data (n = 10). Data are shown as box and whiskers, whiskers are from minimum to maximum, 1-way ANOVA is used to examine the drug effect among groups, if significant, Student’s t test is then used to compare between drug-treated and untreated groups; *P < 0.05.