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. 2019 Aug 22;4(16):e126915. doi: 10.1172/jci.insight.126915

Figure 5. Mitochondrial dynamics are regulated by the RAS/MAPK pathway.

Figure 5

(A) Inducible-Kras cell line AK192 activated with doxycycline exhibits punctate mitochondria, with quantification; n = 100–200 cells. ****P < 0.0001 for tubular, ***P = 0.0002 for fragmented by unpaired t test. Original magnification, ×60. Scale bar: 10 μm. (B) Treatment with MEK inhibitor, PD0325901, induces mitochondrial fusion in KPC cells, with quantification; n = 100–200 cells. ***P = 0.0002 for tubular, ****P < 0.0001 for fragmented by unpaired t test. Original magnification, ×60. Scale bar: 10 μm. (C) Mito Stress assay of KPC cells treated with MEK inhibitor and quantified (D). ****P < 0.0001 by unpaired t test. Data are presented as mean  ±  SEM.