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. 2019 Aug 22;4(16):e125437. doi: 10.1172/jci.insight.125437

Figure 7. Cardiac inflammation is attenuated by coculture medium in a mouse myocardial infarction model.

Figure 7

(A) MI was induced by coronary artery ligation, then CCM from wild-type mouse mMSCs or ANGPTL4-knockout mMSCs was injected i.p. Heart tissues and blood were collected after 2 days for further studies. (B) Circulating IL-6 and IL-1β were not reduced in mice injected with knockout mMSC CCM. n = 5 for each group. The expression levels of inflammatory markers in the heart tissue were assessed by real-time PCR (C, n = 4) and Western blot (D, n = 3). Antiinflammatory activity was not observed in the knockout mMSC-CCM group. Data are represented as mean ± SEM. #P < 0.05; ##P < 0.01; ###P < 0.001 (by Student’s t test or 1-way ANOVA with Bonferroni’s multiple-comparisons test).