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. 2019 Aug 22;4(16):e126457. doi: 10.1172/jci.insight.126457

Figure 8. CTCF binding to PPP2R2B is decreased in T cells of patients with AID.

Figure 8

(A) Schematic representation of PPP2R2B, indicating the location of the region that was analyzed (Amp 1). (B) CTCF motif present in Amp 1. (C) Quantification (ChIP-qPCR) of CTCF binding at Amp 1 in healthy T cells activated and expanded (basal) versus T cells expanded in the presence of TNF-α, n = 3. (D) CTCF binding to Amp 1 in activated T cells for HDs and patients with AID, n = 4. Relative CTCF enrichment was normalized against basal in C or HDs in D. Results are expressed as mean + SEM. *P < 0.05, paired two-tailed t test.