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. Author manuscript; available in PMC: 2019 Oct 4.
Published in final edited form as: Adv Exp Med Biol. 2019;1164:119–139. doi: 10.1007/978-3-030-22254-3_10

Table 2. Examples of differential alternative splicing events in AA PCa, EA PCa, AA normal, and EA normal specimens.

Abbreviations: AA, African American; EA, European American; PCa, prostate cancer; TMPRSS2, transmembrane protease serine 2; AR, androgen receptor; RASGRP2, RAS guanyl releasing protein 2; NF1, neurofibromin 1; BAK1, BCL2 antagonist/killer 1; MTOR, mechanistic target of rapamycin kinase; EGFR, endothelial growth factor receptor; BCL2L1, B-cell lymphoma 2-like 1; PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; ITGA4, integrin subunit alpha 4; MET, MET proto-oncogene, receptor tyrosine kinase; FGFR3, fibroblast growth factor receptor 3; TSC2, tuberous sclerosis complex subunit 2.

Patient groups # of AS genes Examples
AA PCa and EA PCa 158 TMPRSS2, AR
AA PCa vs. EA PCa 1,876 RASGRP2, NF1, BAK1
AA normal vs. EA normal 2,205 MTOR, EGFR, BCL2L1
AA PCa and AA normal 644 PIK3CD, ITGA4, MET
AA PCa vs. AA normal 1,575 FGFR3, TSC2