Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Frequency of Somatic Mutations and Alterations in NSCLC
| Gene | Alteration type | Frequency in NSCLC |
|---|---|---|
| EGFR | Mutation | 10–35% |
| KRAS | Mutation | 15–25% |
| FGFR1 | Amplification | 20% |
| PTEN | Mutation | 4–8% |
| DDR2 | Mutation | ~4% |
| ALK | Rearrangement | 3–7% |
| HER2 | Mutation | 2–4% |
| MET | Amplification | 2–4% |
| BRAF | Mutation | 1–3% |
| PIK3CA | Mutation | 1–3% |
| AKT1 | Mutation | 1% |
| MEK1 | Mutation | 1% |
| NRAS | Mutation | 1% |
| RET | Rearrangement | 1% |
| ROS1 | Rearrangement | 1% |
