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. 2019 Sep 5;4(17):e130356. doi: 10.1172/jci.insight.130356

Figure 2. Metabolome features of 60 APA samples.

Figure 2

Unguided hierarchical clustering analysis (A) and orthogonal partial least squares discriminant analysis (ortho-PLSDA) (B) of metabolome profiles between APAs with KCNJ5 and CACNA1D mutations. (C) Shown are significant differences in metabolites of the purine metabolism and intensities of adenosine monophosphate (AMP), adenosine diphosphate (ADP), and d-Ribulose 5-phosphate between KCNJ5- and CACNA1D-mutated APAs (adjusted P = 0.010, 0.003, and 0.047, respectively). (D) Intensities of 1-phosphatidyl-d-myo-inositol between KCNJ5- and CACNA1D-mutated APAs (adjusted P = 0.009). *adjusted P < 0.05; **adjusted P < 0.01. (E) Significant changes in intensities between KCNJ5- and CACNA1D-mutated APAs of 18-oxocoritsol (P = 0.020) and 18-hydroxycortisol (P < 0.001). Mann-Whitney U test was used for statistical analysis. *P < 0.05; **P < 0.01. The box plots depict the minimum and maximum values (whiskers), the upper and lower quartiles, and the median. The length of the box represents the interquartile range.