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. 2019 Sep 5;4(17):e130402. doi: 10.1172/jci.insight.130402

Figure 4. HFD calorie-restricted feeding for 2 weeks reduces the frequency of neuronal firing in response to CCK-8 and leptin in vivo.

Figure 4

(A) Summary bar graph showing 24 hours of cumulative calorie intake in LFD, HFD, and HFD calorie-restricted groups (n = 6 in each group). Data are represented as mean ± SEM. *P < 0.05 vs. LFD. (B) Representative recordings of NG neuron responses to intra–superior pancreaticoduodenal artery infusions of CCK-8 (60 pmol/kg) and leptin (60 pmol/kg) in LFD-fed or HFD calorie-restricted–fed rats. (C) Summary histogram showing single-unit discharges in response to CCK-8 and leptin in rats given an LFD (n = 6) and HFD calorie-restricted diet, respectively (n = 6). Data are represented as mean ± SEM. Student’s t test. *P < 0.05 vs. LFD stimulated with CCK-8; #P < 0.05 vs. LFD stimulated with leptin.